The regulatory component of the human genome is much less well defined but based upon conservation is 2 to 3 times larger than the coding region (Cooper et al., 2010). The large number of variants that will be identified generates an urgent need for bioinformatics and computational approaches capable of prioritizing the variants most likely to underlie the observed association, for further biological testing. One feasible solution is to catalog all DNA variants in the LD region of the association, both common and rare, by utilizing next-generation sequencing (NGS) technology. GWAS target common DNA variants, which could either directly contribute to the clinical phenotype or provide an indirect proxy for functional variants, which are in linkage disequilibrium (LD) with the SNP being tested. Recent studies of complex diseases and phenotypes have tended to focus on genome-wide association studies (GWAS) employing hundreds of thousands of single nucleotide polymorphisms (SNPs

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“I also want to thank our District 3 businesses, including the GSBA and nightlife stakeholders in Capitol Hill, who’ve shown their support in developing this bill. “But for the two people senselessly murdered, and for their families, the closure comes too late. I want to thank City Attorney Davison, the Mayor’s Office, and Councilmember Hollingsworth and her wonderful staff for their invaluable contributions in making today’s final vote happen. “I’m proud that we took a collaborative and strategic approach to developing these regulations. This pub-related article is a stu

A positive and negative ΔSV implies that the alternative allele will result in a gain or loss of binding affinity, respectively. Nt is the total number of experimentally validated binding sequences for each TFBS in the TRANSFAC database